The role of collagen in scar formation

The role of collagen in scar formation

Introduction to Scar Formation

A scar is a mark that is left on the skin after an injury or wound has healed.

Scars are composed of collagen, which is a protein found in the body that helps to repair damaged tissues and form new tissue during healing.

In some cases, scarring can leave behind permanent changes in the texture and appearance of the skin.

The size, shape, color, and depth of scars vary depending on factors such as the type of wound, its location on the body, how severe it was at first impact, any treatments used to address it during recovery time periods (e.g. antibiotics or surgical interventions), genetics and other influencing variables.

Key stages of scar formation

There are four key stages in scar formation:

  • The initial inflammatory response, triggered by injury to the skin, causes an influx of blood and white blood cells to the damaged tissue, which leads to oedema and haemorrhage.
  • Granulation tissue then forms at the wound site and continues to grow until it covers the wound completely. This is a soft and pinkish-red tissue that is rich in collagen, proteoglycans and matrix metalloproteases (MMPs).
  • Collagen deposition occurs next as granulation tissue degenerates and fibroblasts lay down collagen I in a haphazard arrangement known as type III collagen. Between three months and one year post-wound, this type III collagen is replaced with type I collagen arranged in a parallel manner characteristic of mature scars.
  • Scar maturation is completed once this process is complete; as such, it marks the end of scar formation.

The degree of scarring ultimately depends on how each stage unfolds; therefore, it is important for clinicians to be aware of interventions that can minimise scarring at each stage

What role does collagen play in scarring?

Collagen is the most abundant protein in your body. It’s present in your skin, bones, blood vessels and digestive system. Collagen is what makes up connective tissue and gives your skin strength and elasticity.

The word collagen has become a buzzword that’s found on many health and beauty products, but you may be wondering: What is collagen exactly? Where does it come from? And how can adding more of it to our diets benefit our health?

As you age, your body produces less collagen than before. This means you have to find ways to support the production of new collagen through diet or supplementation.

Working with your wounds to minimise scarring

Regardless of the scar treatment you choose, there is a lot you can do to ensure minimal scarring. Here are some tips to help you get the most from your treatment:

  • Avoid excessive rubbing against your skin. While it’s okay for massage therapists to use a light touch when treating a patient’s face, it is important not to rub in the same way when treating scars. Touching scars too aggressively can cause them to form puckered creases or irregular lines that could become permanent scars or even keloids (a type of raised scar).
  • Wear sunscreen daily. Excessive sun exposure increases the chances of developing brown spots and early wrinkles, making your skin vulnerable to more damage from UV rays. Because UV rays can also cause scars, sun protection is especially important for patients with blemishes, cuts, burns and other visible wounds that may trigger people’s negative reactions if exposed because they look like “old” scars!

Collagen plays a key role in the healing process, but a wide range of other factors are also important.

  • It’s true that collagen plays a key role in healing. However, it’s important to recognize that there are many other factors at play as well.
  • Factors like genetics, skin tone, the location of the wound, and the size and depth of the wound can all impact scarring. For example, darker skin tones tend to produce more noticeable scars than lighter ones, and wounds on areas like hands or joints may not heal as well as those on less mobile areas.
  • Because of these other variables, it’s inaccurate to say that you can prevent scarring by boosting your collagen intake alone.

Factors that Affect Scar Formation

Wounds located on areas like joints, knuckles, or other areas with high movement may be more likely to become hypertrophic or keloid scars due to increased tension.

The depth of the wound also plays a role in scar formation; deeper wounds have higher chances for developing into raised, red scars.

Infection can further exacerbate this risk as it can cause inflammation which increases collagen production leading to more visible scarring.

Additionally, certain individuals might be predisposed to more severe scarring based on their age and genetics – younger people are generally at higher risk for forming thicker scars due to increased collagen production while those with darker skin tones are prone to hyperpigmentation around any injury site even after healing has occurred.

Finally, an individual’s overall health and nutrition is another important factor in determining how well they will heal from injuries; proper nourishment helps ensure healthy tissue regeneration which reduces the chance of permanent scarring.

Types of Scars

Atrophic scars: Atrophic scars are depressions in the skin and can be caused by a variety of conditions. Acne is one of the most common causes of atrophic scarring, as it causes inflammation that damages collagen fibers in the lower layers of skin. Chickenpox also commonly leads to atrophic scarring due to its ability to damage collagen fibers during an outbreak. In some cases, atrophic scars can become permanent if they are not treated promptly or correctly. Fortunately, many treatments exist that help reduce the appearance of these indented marks on the skin surface. These include laser therapy, dermal fillers, and micro-needling procedures which all work by stimulating new collagen production in order to plump up sunken areas on the face or body.

Hypertrophic scars: Hypertrophic scars, also known as a keloid scar, are raised and red in appearance. They typically appear thicker than the surrounding skin tissue and can be itchy or painful to touch. Hypertrophic scars develop when there is an overproduction of collagen during the healing process. Common causes of hypertrophic scars include burns, boils, surgical incisions, acne cysts, vaccinations and insect bites. Treatment methods for hypertrophic scars may include steroid injections to reduce inflammation or surgery to remove excess tissue. Some people opt for natural treatments such as vitamin E oil applied directly on the area or silicone gel sheeting placed over the scarring to help soften and flatten the scar’s appearance.

Keloid scars: Keloid scars are a type of raised scar that can grow larger than the original wound. They typically appear as an overgrowth of skin tissue, and may be flesh-colored or darker in color compared to your natural skin tone. These types of scars are most commonly caused by cuts, piercings, burns, acne, and other types of wounds. In some individuals they can cause discomfort due to sensitivity or itching sensation. Treatment options for keloid scars include topical creams and ointments containing corticosteroids; laser therapy; cryotherapy (freezing); pressure therapy; and surgery – although this should only be considered if other treatments have failed to improve the scar’s appearance.

Contracture scars: Contracture scars are typically caused by extensive damage to the skin due to burns or other injuries. This type of scarring causes the skin to contract and tighten, leading to a restricted range of motion in affected areas. Contracture scars can be particularly painful and may require specialized treatment such as topical creams or surgery depending on their severity. Collagen plays an important role in helping minimize these types of scars by aiding in the healing process and helping keep the surrounding tissue healthy. Additionally, collagen production helps strengthen weakened connective tissues around wounds, which can help reduce contraction of scarred tissue and improve overall mobility.

Treatments for Scars

Topical creams and ointments: Topical creams and ointments are a popular choice for managing scarring. These products contain ingredients such as silicone, vitamin E, onion extract, aloe vera gel or tea tree oil that help to soothe inflammation, promote healing of skin tissue and improve the overall appearance of scars. Additionally, they may be combined with other treatments like laser therapy or steroid injections for further improvement.

Injections: Corticosteroid injections are an effective treatment for reducing the appearance of scars. These injections work by targeting collagen, a protein found in connective tissue that helps to create scar tissue. By injecting corticosteroids into the scarred area, it can help to reduce inflammation which leads to reduced redness and size of the scar. In some cases, if done multiple times over a period of time, these treatments can even help improve skin texture and overall appearance of the affected area.

Laser therapy: Laser therapy is a non-invasive treatment option for scar tissue. During the procedure, highly concentrated beams of light are used to target and break down collagen fibers in the scarred area. This helps to reduce discoloration as well as soften and smooth out the appearance of scars. Laser therapy may be an effective solution for reducing all types of scars, including hypertrophic, keloid, acne, burn or surgical ones. While laser treatments may not completely remove the scarring from your skin, they can help make it much less noticeable over time with repeated use.

Surgery: Surgery can be a necessary step for some people who are looking to reduce the appearance of scars. During surgery, scar tissue may be removed or altered in order to make it less visible. Depending on the type and severity of the scar, different methods may need to be utilized such as excision, dermabrasion, laser resurfacing etc. Recovery time after surgery is typically several weeks but results vary depending on individual cases.

The Role of Collagen in Scar Treatment

Collagen supplements: Collagen supplements have been a popular topic of debate in recent years, with many people believing that they can help to reduce the appearance of scars. It is thought that collagen supplements aid the healing process by helping to promote healthy skin cells and tissue regeneration. The main benefit of taking these supplements is believed to be increased elasticity and hydration within the skin, which can lead to improved scarring. In addition, it has also been suggested that collagen may reduce inflammation around wounds or injuries, reducing pain and discomfort associated with scarring. However, more research is needed before any firm conclusions can be made regarding the effectiveness of collagen supplementation for improving scar appearance.

Τopical collagen products: Topical collagen products: Many people believe that using topical collagen-based products, such as creams and serums, may help improve the appearance of scars. These products can be applied directly onto scar tissue to nourish the skin with beneficial nutrients and promote healthy healing. The use of collagen-based topicals is thought to stimulate new cell growth in the area, which helps reduce scar visibility over time. However, it’s important to note that results vary from person to person and are not guaranteed. It is always recommended to speak with a healthcare professional before trying any type of topical treatment for scars.

Collagen injections: Collagen injections involve injecting a synthetic or natural collagen filler into an indented scar to reduce its appearance. This treatment is usually done in combination with other treatments, such as laser resurfacing and dermabrasion, for best results. The effects of collagen injection typically last from three months up to two years, depending on how quickly your body naturally breaks down the injected material. It’s important that you follow your doctor’s instructions on aftercare and use sun protection when exposed to sunlight in order to maintain results and avoid any further damage or discoloration of the skin.


Collagen is a vital component of the scar formation process. It helps to form new tissue which replaces damaged skin after injury, and can also reduce inflammation and improve healing time. In some cases, collagen supplementation may be necessary for optimal scar reduction or prevention. Additionally, there are a variety of treatments available that can help reduce the appearance of existing scars and prevent them from becoming worse over time. These include topical creams, laser therapy, chemical peels, dermabrasion, steroid injections or surgery. Depending on your individual needs it is important to speak with a healthcare professional in order to determine which treatment option will best suit you.